Description

Valine, n-(Methoxy-D3-Carbonyl)-3-Methyl- is a stable isotope-labeled derivative of the essential amino acid L-valine, specifically deuterated on the methoxy carbonyl group. This compound is of critical importance for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and reproducibility in analytical measurements. It is primarily needed by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in metabolomics, pharmacokinetic studies, and the development of novel therapeutic agents.

Application

• Mass Spectrometry Internal Standard: Serves as a critical quantitative reference in LC-MS/MS and GC-MS analyses for accurate measurement of valine and related metabolites.
• Biomedical Research: Used in tracer studies to investigate amino acid metabolism, protein turnover, and metabolic pathways in cell cultures and animal models.
• Pharmaceutical Development: Essential for conducting precise bioavailability, bioequivalence, and pharmacokinetic (PK) studies of drug candidates.
• Clinical Diagnostics: Enables the accurate quantification of valine in patient samples for the diagnosis and monitoring of metabolic disorders like Maple Syrup Urine Disease (MSUD).
• Nutraceutical & Sports Science Research: Applied in studies examining muscle protein synthesis, exercise physiology, and the efficacy of amino acid supplements.
• Food & Feed Analysis: Used in advanced methods to determine the precise amino acid composition and authenticity of protein-rich products.

Basic Information

Product Name	Valine, n-(Methoxy-D3-Carbonyl)-3-Methyl-
CAS No.	920757-35-3
Molecular Formula	C9H14D3NO3
Molecular Weight	190.24 g/mol
Synonyms	N-(Methoxy-d3-carbonyl)-3-methyl-L-valine; L-Valine, N-[(methoxy-d3)carbonyl]-3-methyl-; (2S)-2-[[(Methoxy-d3)carbonyl]amino]-3-methylbutanoic acid; Deuterated Methoxycarbonyl Valine; d3-MOC-Valine; Stable Isotope Labeled Valine Derivative; Internal Standard for Valine MS
EINECS	Contact for details

Quality Control

Every batch of Valine, n-(Methoxy-D3-Carbonyl)-3-Methyl- is produced and analyzed under strict quality management protocols to ensure the highest isotopic and chemical purity for sensitive analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing isotopic enrichment (D, atom %), chemical purity, and confirming the absence of critical unlabeled impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D, atom %)	≥ 98.0%
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.