Description

Boronic Acid, B-(2,5-Difluoro-3-Hydroxyphenyl)- is a high-purity, multifunctional arylboronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both boronic acid and phenolic hydroxyl groups, makes it an exceptionally versatile reagent for forming carbon-carbon and carbon-heteroatom bonds. This compound is essential for researchers and manufacturers in the pharmaceutical and advanced materials sectors who require reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging the difluoro and hydroxyl substituents for enhanced bioactivity and selectivity.
• Material Science & OLED Development: Serves as a monomer or building block for creating organic semiconductors, fluorescent sensors, and electron-transport materials in organic light-emitting diodes (OLEDs).
• Protease Inhibitor Research: Utilized as a core scaffold in the design and synthesis of boronic acid-based protease inhibitors, such as proteasome and serine protease inhibitors.
• Polymer Chemistry: Employed in the synthesis of functional polymers and dendrimers via its reactive boronic acid group for applications in sensing and smart materials.
• Bioconjugation & Labeling: Facilitates the site-specific modification of biomolecules (e.g., sugars, proteins) through boronate ester formation for diagnostic and therapeutic applications.

Basic Information

Product Name	Boronic Acid, B-(2,5-Difluoro-3-Hydroxyphenyl)-
CAS No.	919355-35-4
Molecular Formula	C6H5BF2O3
Molecular Weight	173.91 g/mol
Synonyms	(2,5-Difluoro-3-hydroxyphenyl)boronic acid; 3-Hydroxy-2,5-difluorophenylboronic acid; 2,5-Difluoro-3-hydroxybenzeneboronic acid; B-(2,5-Difluoro-3-hydroxyphenyl)boronic acid; 2,5-Difluoro-3-hydroxy phenyl boronic acid; (3-Hydroxy-2,5-difluorophenyl)boronic acid
EINECS	Contact for details

Quality Control

Our Boronic Acid, B-(2,5-Difluoro-3-Hydroxyphenyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.