Description

(S)-(+)-2,2'-Bis[Di(3,5-Di-I-Propyl-4-Dimethylaminophenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl,Min.97% is a high-purity, chiral bisphosphine ligand of significant importance in asymmetric catalysis. This compound matters because it enables highly enantioselective transformations, a critical requirement for the efficient synthesis of single-enantiomer pharmaceuticals and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel synthetic routes and optimizing production processes.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, a cornerstone reaction in active pharmaceutical ingredient (API) manufacturing.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in complex drug molecules, including those for cardiovascular, central nervous system, and oncological therapies.
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and insecticides to enhance efficacy and reduce environmental impact.
• Fine Chemical Manufacturing: Enables the production of high-value chiral building blocks, flavors, and fragrances with precise stereochemical control.
• Academic & Industrial R&D: Serves as a key tool for methodology development in academic laboratories and for scaling up catalytic processes in industrial settings.
• Catalyst Library Development: A valuable component in screening libraries for discovering new asymmetric reactions and optimizing catalyst performance.

Basic Information

Product Name	(S)-(+)-2,2'-Bis[Di(3,5-Di-I-Propyl-4-Dimethylaminophenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl, Min. 97%
CAS No.	919338-66-2
Molecular Formula	C78H108I4N4O2P2
Molecular Weight	1684.31 g/mol
Synonyms	(S)-DTBM-SEGPHOS; (S)-3,5-Di-tert-butyl-4-methoxyphenyl-SEGPHOS; (S)-DTBM-Segphos; (S)-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-6,6'-dimethoxy-1,1'-biphenyl; (S)-DTBM SegPhos; (S)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; LICAND DTBM-SEGPHOS; Asymmetric Hydrogenation Ligand DTBM-SEGPHOS
EINECS	Contact for details

Quality Control

Our (S)-DTBM-SEGPHOS is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Every lot undergoes comprehensive analysis, including HPLC for purity and chiral analysis to confirm enantiomeric excess. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting key specifications to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. This material is strictly light-sensitive and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 97.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Solubility Test	Soluble in common organic solvents (Toluene, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.