Description

Methyl (3R)-3-Amino-3-(2-Fluorophenyl)Propanoate CAS NO 918864-97-8 is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) requiring specific stereochemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in the areas of central nervous system (CNS) and cardiovascular drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological and cardiovascular pathways.
• Asymmetric Synthesis: Used in the construction of enantiomerically pure molecules for medicinal chemistry research and process development.
• API Development: Serves as a critical precursor in the research and scale-up production of new chemical entities (NCEs) and generic APIs.
• Chemical Biology Research: Employed as a probe or building block in the study of enzyme mechanisms and receptor-ligand interactions.
• Process Chemistry: Utilized in route scouting and optimization for the efficient, scalable manufacturing of target molecules.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	Methyl (3R)-3-Amino-3-(2-Fluorophenyl)Propanoate
CAS No.	918864-97-8
Molecular Formula	C10H12FNO2
Molecular Weight	197.21 g/mol
Synonyms	(R)-Methyl 3-amino-3-(2-fluorophenyl)propanoate; Methyl (R)-3-amino-3-(2-fluorophenyl)propionate; (3R)-3-Amino-3-(2-fluorophenyl)propanoic acid methyl ester; 2-Fluorophenylalanine methyl ester; (R)-3-Amino-3-(2-fluorophenyl)propionic acid methyl ester; Methyl 3-amino-3-(o-fluorophenyl)propanoate; (R)-Methyl 3-amino-3-(o-fluorophenyl)propanoate; 918864-97-8
EINECS	Contact for details

Quality Control

Our Methyl (3R)-3-Amino-3-(2-Fluorophenyl)Propanoate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.