Description

(S)-n-Fmoc-5,5,5,5,5,5-Hexafluoroleucine CAS NO 918667-71-7 is a specialized, non-natural amino acid derivative featuring a hexafluorinated side chain, protected by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is critical for introducing unique steric, electronic, and lipophilic properties into synthetic peptides, significantly enhancing their metabolic stability and membrane permeability. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based therapeutics, diagnostic agents, and advanced materials where fluorination is a key design strategy.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of fluorinated peptides.
• Pharmaceutical Research: Incorporation into novel peptide drug candidates to improve bioavailability, proteolytic stability, and target binding affinity.
• Chemical Biology Probes: Synthesis of labeled peptides for studying protein-protein interactions, enzyme mechanisms, and cellular uptake.
• Material Science: Building block for creating fluorinated peptidomimetics and polymers with specialized surface properties.
• Agrochemical Development: Used in research for designing bioactive peptides with enhanced environmental stability.

Basic Information

Product Name	(S)-n-Fmoc-5,5,5,5,5,5-Hexafluoroleucine
CAS No.	918667-71-7
Molecular Formula	C₂₂H₂₀F₆NO₄
Molecular Weight	476.39 g/mol
Synonyms	Fmoc-Hexafluoroleucine-OH; Fmoc-(S)-5,5,5,5,5,5-Hexafluoroleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5,5,5,5,5,5-hexafluoroleucine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4,4,4-trifluoro-3-(trifluoromethyl)butanoic acid; Fmoc-Leu(6F)-OH; Fmoc-Hfl-OH; Nα-Fmoc-5,5,5,5,5,5-hexafluoro-L-leucine
EINECS	Contact for details

Quality Control

Our (S)-n-Fmoc-5,5,5,5,5,5-Hexafluoroleucine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.