Description

Piperazine-1,2-Dicarboxylic Acid 1-(9H-Fluoren-9-Ylmethyl) Ester is a specialized Fmoc-protected amino acid derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in enabling the controlled synthesis of complex peptides and peptidomimetics, particularly those incorporating piperazine-based scaffolds. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled, sequential assembly of peptides containing piperazine-2-carboxylic acid or its derivatives.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of active pharmaceutical ingredients (APIs), especially for drugs targeting neurological and cardiovascular diseases.
• Peptidomimetic Design: Used to create non-natural peptide analogs with enhanced metabolic stability, bioavailability, and receptor selectivity for drug discovery programs.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening to identify new lead compounds.
• Bioconjugation: Can be utilized in the synthesis of peptide-based linkers or tags for bioconjugation applications in diagnostics and targeted drug delivery systems.
• Academic & Industrial Research: A fundamental reagent for investigating structure-activity relationships (SAR) and synthesizing reference standards in chemical biology.

Basic Information

Product Name	Piperazine-1,2-Dicarboxylic Acid 1-(9H-Fluoren-9-Ylmethyl) Ester
CAS No.	918435-70-8
Molecular Formula	C21H20N2O4
Molecular Weight	364.40 g/mol
Synonyms	Fmoc-Pip(2-COOH)-OH; 1-Fmoc-piperazine-2-carboxylic acid; (2S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]piperazine-2-carboxylic acid; Fmoc-L-piperazine-2-carboxylic acid; Fmoc-Pip(2-COOH); 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]piperazine-2-carboxylic acid; N-α-Fmoc-piperazine-2-carboxylic acid; Piperazine-2-carboxylic acid, 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Piperazine-1,2-Dicarboxylic Acid 1-(9H-Fluoren-9-Ylmethyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the exacting standards required for pharmaceutical R&D and cGMP manufacturing. Comprehensive Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.