Description

Tigatuzumab CAS NO 918127-53-4 is a humanized monoclonal antibody designed as a death receptor 5 (DR5) agonist for targeted cancer therapy. Its primary value lies in its ability to selectively induce apoptosis in tumor cells expressing DR5, offering a potential therapeutic pathway with a distinct mechanism of action. This investigational agent is critical for pharmaceutical R&D, preclinical studies, and clinical trial material (CTM) supply for oncology research programs targeting solid tumors and hematological malignancies.

Application

• Oncology Research & Drug Development: As a key investigational biologic for studying DR5-mediated apoptosis signaling pathways in cancer cells.
• Preclinical Study Material: Used in in vitro and in vivo models to evaluate antitumor efficacy, pharmacokinetics, and safety profiles.
• Clinical Trial Manufacturing: Sourced as a critical raw material or reference standard for the GMP production of clinical trial batches.
• Biopharmaceutical Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control of biologic products.
• Mechanism of Action Studies: Utilized in research to understand resistance mechanisms and combination therapies with other anticancer agents.
• Biologics Licensing Application (BLA) Support: Provides necessary documentation and characterization data for regulatory submissions.

Basic Information

Product Name	Tigatuzumab
CAS No.	918127-53-4
Molecular Formula	Data on file
Molecular Weight	Approx. 150 kDa
Synonyms	CS-1008; Anti-DR5 Agonistic Monoclonal Antibody; TRA-8; Tigatuzumab; Humanized Anti-TRAIL Receptor-2 Monoclonal Antibody; Anti-TNFRSF10B Agonistic Antibody; Conatumumab (related agent); Lexatumumab (related agent); Apomab (related agent)
EINECS	Contact for details

Quality Control

Our Tigatuzumab is manufactured and controlled under a stringent quality management system. Each batch is subjected to comprehensive analytical testing including purity by SEC-HPLC, biological activity assays, and identity confirmation to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing purity, endotoxin levels, sterility (where applicable), and other critical quality attributes are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be used immediately or stored according to validated stability protocols, typically at 2-8°C for short-term use. This product is hygroscopic (moisture-sensitive); ensure containers are sealed under controlled humidity conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (SEC-HPLC / MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95.0% (Monomer)
Protein Content (UV/A280)	90.0% - 110.0% of label claim
Biological Activity (Cell-based Assay)	Reported value per COA
Endotoxin	< 1.0 EU/mg
Host Cell Protein (HCP)	< 100 ppm
Residual DNA	< 10 pg/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.