Description

Fmoc-D-3-Methoxyphenylalanine CAS NO 917099-04-8 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical building block in the development of complex peptide-based pharmaceuticals and research tools, offering precise stereochemical control. It is primarily utilized by research institutions, pharmaceutical R&D departments, and CROs/CDMOs specializing in peptide drug discovery and production.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tert-butyl strategy, enabling the controlled assembly of peptide chains.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptidomimetic Design: Used to incorporate the D-3-methoxyphenylalanine moiety into peptide analogs to enhance metabolic stability, bioavailability, and receptor binding affinity.
• Bioconjugation and Labeling: Facilitates the site-specific modification of peptides for diagnostic, imaging, or therapeutic targeting applications.
• Chemical Biology Research: Employed in the study of protein-protein interactions, enzyme mechanisms, and the development of novel bioactive peptides.
• Library Synthesis: A valuable component for generating diverse combinatorial peptide libraries for high-throughput screening in drug discovery.

Basic Information

Item	Detail
Product Name	Fmoc-D-3-Methoxyphenylalanine
CAS No.	917099-04-8
Molecular Formula	C25H23NO5
Molecular Weight	417.45 g/mol
Synonyms	Fmoc-D-3-Methoxy-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methoxy-D-phenylalanine; Fmoc-D-3-Methoxyphenylalanine; Fmoc-D-(3-MeO)Phe-OH; N-Fmoc-3-methoxy-D-phenylalanine; D-3-Methoxyphenylalanine, N-Fmoc derivative; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-methoxyphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-3-Methoxyphenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical and chiral purity suitable for sensitive pharmaceutical research. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.