Description

Allopurinol-D2 is a deuterium-labeled analog of the xanthine oxidase inhibitor allopurinol, specifically designed for use as an internal standard in analytical chemistry. This high-purity stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors who require precise measurement of allopurinol and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the precise quantification of allopurinol in biological matrices (plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic Research: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Metabolite Profiling: Used in studies investigating the metabolic pathways and biotransformation of allopurinol within biological systems.
• Bioanalytical Method Development: Critical for developing, validating, and transferring robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Therapeutic Drug Monitoring (TDM): Supports assays designed to monitor allopurinol concentrations in patient samples to optimize dosing and ensure therapeutic efficacy.
• Reference Material: Serves as a certified reference material (CRM) for calibrating instruments and verifying analytical procedures in quality control laboratories.

Basic Information

Item	Detail
Product Name	Allopurinol-D2
CAS No.	916979-34-5
Molecular Formula	C5H2D2N4O
Molecular Weight	138.13 g/mol
Synonyms	1H-Pyrazolo[3,4-d]pyrimidin-4-ol-2,6-d2; 4-Hydroxypyrazolo[3,4-d]pyrimidine-2,6-d2; Allopurinol (2,6-d2); [2,6-D2]Allopurinol; Deuterated Allopurinol; Allopurinol-d2; Isotopically Labeled Allopurinol; HPP-d2
EINECS	Contact for details

Quality Control

Our Allopurinol-D2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and mass spectrometry to confirm isotopic enrichment and positional labeling, and HPLC for chemical and isotopic purity assessment. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing batch-specific results. Our quality commitment ensures the material meets the stringent requirements for use in regulated bioanalytical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Isotopic Purity (HPLC-MS)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.