Description

3-Methoxy-5-(Trifluoromethyl)Benzyl Cyanide, also known as 3-(Cyanomethyl)-5-Methoxybenzotrifluoride, is a versatile and high-value aromatic nitrile building block. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its trifluoromethyl and cyano groups serve as key functional handles for further derivatization. It is primarily sought after by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), advanced crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Serves as a crucial precursor for advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Liquid Crystal & OLED Materials: Used in the synthesis of specialty organic compounds for electronic displays and optoelectronic devices.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, cyano group transformations, and as a scaffold for constructing complex heterocycles in fine chemical production.
• Chemical Research & Development: Essential for academic and industrial R&D labs exploring new synthetic methodologies and material properties.

Basic Information

Product Name	3-Methoxy-5-(Trifluoromethyl)Benzyl Cyanide / 3-(Cyanomethyl)-5-Methoxybenzotrifluoride
CAS No.	916421-02-8
Molecular Formula	C10H8F3NO
Molecular Weight	215.17 g/mol
Synonyms	5-Methoxy-3-(trifluoromethyl)benzyl cyanide; 1-[3-Methoxy-5-(trifluoromethyl)phenyl]acetonitrile; 3-Methoxy-α-(trifluoromethyl)benzeneacetonitrile; (3-Methoxy-5-(trifluoromethyl)phenyl)acetonitrile; 3-Cyanomethyl-5-methoxybenzotrifluoride; 3-Methoxy-5-trifluoromethylphenylacetonitrile; 5-(Cyanomethyl)-1-methoxy-3-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our 3-Methoxy-5-(Trifluoromethyl)Benzyl Cyanide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.