Description

1-(Bromomethyl)-3-Methoxy-5-(Trifluoromethyl)Benzene, 3-(Bromomethyl)-5-(Trifluoromethyl)Phenyl Methyl Ether is a versatile and high-value aromatic building block containing both bromomethyl and trifluoromethyl functional groups. This compound is critical for introducing specific molecular motifs in advanced chemical synthesis, offering unique reactivity and physicochemical properties. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the creation of novel monomers and polymers, such as liquid crystals and specialty polymers with tailored electronic or surface properties.
• Fluorine Chemistry: An essential reagent for introducing the trifluoromethylphenyl moiety into complex molecules, a common strategy in drug discovery to optimize potency and pharmacokinetics.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring high-purity, specialized aromatic intermediates.

Basic Information

Product Name	1-(Bromomethyl)-3-Methoxy-5-(Trifluoromethyl)Benzene, 3-(Bromomethyl)-5-(Trifluoromethyl)Phenyl Methyl Ether
CAS No.	916421-00-6
Molecular Formula	C10H8BrF3O
Molecular Weight	281.07 g/mol
Synonyms	3-(Bromomethyl)-5-(trifluoromethyl)anisole; 1-Bromomethyl-3-methoxy-5-trifluoromethylbenzene; 5-(Bromomethyl)-1-methoxy-3-(trifluoromethyl)benzene; α-Bromo-3-methoxy-5-(trifluoromethyl)toluene; 3-Methoxy-5-(trifluoromethyl)benzyl bromide; (3-Methoxy-5-(trifluoromethyl)phenyl)methyl bromide
EINECS	Contact for details

Quality Control

Our 1-(Bromomethyl)-3-Methoxy-5-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.