Description

3-[4-Fluoro-2-(Trifluoromethyl)Phenyl]Propionic Acid, also known as 4-Fluoro-2-(trifluoromethyl)hydrocinnamic acid, is a high-value fluorinated aromatic building block. This compound is prized for its unique molecular structure, which combines a phenylpropionic acid backbone with strategically placed fluorine and trifluoromethyl groups, offering enhanced lipophilicity and metabolic stability. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a precursor for developing advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved biological activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Used in the synthesis of fluorinated organic molecules for electronic applications, contributing to the tuning of electronic properties and material stability.
• Advanced Material Science: Acts as a building block for creating specialty polymers and coatings with specific chemical resistance and surface properties.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring novel organic reactions and creating compound libraries for high-throughput screening.

Basic Information

Product Name	3-[4-Fluoro-2-(Trifluoromethyl)Phenyl]Propionic Acid
CAS No.	916420-73-0
Molecular Formula	C10H8F4O2
Molecular Weight	236.16 g/mol
Synonyms	4-Fluoro-2-(trifluoromethyl)hydrocinnamic acid; 3-(4-Fluoro-2-(trifluoromethyl)phenyl)propanoic acid; 2-(Trifluoromethyl)-4-fluorohydrocinnamic acid; 4-Fluoro-α,α,α-trifluoro-o-toluic acid, 3-carboxyethyl derivative; 3-(4-Fluoro-2-trifluoromethylphenyl)propionic acid; F-TFM-PPA; 916420-73-0
EINECS	Contact for details

Quality Control

Our production of 3-[4-Fluoro-2-(Trifluoromethyl)Phenyl]Propionic Acid adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP principles and ISO-aligned processes guarantees a reliable supply of high-purity material for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.