Description

3-Methyl-5-(Trifluoromethoxy)Benzamide is a high-purity, fluorinated aromatic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethoxy group imparts desirable metabolic stability and lipophilicity. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors engaged in innovative drug discovery and crop protection programs.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Serves as a precursor in the development of next-generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Used in the creation of specialty polymers and advanced organic materials with unique electronic or surface properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry for designing novel ligands and catalysts used in cross-coupling reactions.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3-Methyl-5-(Trifluoromethoxy)Benzamide
CAS No.	916420-53-6
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	3-Methyl-5-(trifluoromethoxy)benzamide; 5-(Trifluoromethoxy)-3-methylbenzamide; 3-Methyl-5-(trifluoromethoxy)benzoic acid amide; m-Tolyl-5-(trifluoromethoxy)carboxamide; Benzamide, 3-methyl-5-(trifluoromethoxy)-; 916420-53-6; 3-Methyl-5-trifluoromethoxybenzamide
EINECS	Contact for details

Quality Control

Our 3-Methyl-5-(Trifluoromethoxy)Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.