Description

(S)-3-Azido-2-(4-Fluorobenzyl)Propanamide is a chiral, fluorinated azido compound that serves as a versatile and high-value building block in advanced organic synthesis. Its unique structure, featuring an azido group and a fluorinated benzyl moiety, makes it a critical intermediate for the development of novel pharmaceuticals and bioactive molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the synthesis of protease inhibitors, targeted therapeutics, and other complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially protease inhibitors and enzyme-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its reactive azido group and fluorinated aromatic ring.
• Peptidomimetic Synthesis: Employed in the construction of peptide analogs and mimetics where the azido group enables "click chemistry" for efficient conjugation.
• Bioconjugation and Probe Development: The azido functionality allows for bioorthogonal labeling via copper-catalyzed azide-alkyne cycloaddition (CuAAC), useful in creating diagnostic probes.
• Chemical Biology: Serves as a tool compound for studying enzyme mechanisms and protein interactions where fluorine acts as a spectroscopic or steric probe.
• Agrochemical Research: Potential intermediate in the discovery of new herbicides or fungicides leveraging the fluorobenzyl group for enhanced bioactivity and stability.

Basic Information

Product Name	(S)-3-Azido-2-(4-Fluorobenzyl)Propanamide
CAS No.	916322-86-6
Molecular Formula	C₁₀H₁₁FN₄O
Molecular Weight	222.22 g/mol
Synonyms	(S)-2-(4-Fluorobenzyl)-3-azidopropanamide; (S)-3-Azido-2-(4-fluorobenzyl)propionamide; L-3-Azido-2-(4-fluorobenzyl)propanamide; (2S)-2-[(4-Fluorophenyl)methyl]-3-azidopropanamide; Propanamide, 3-azido-2-[(4-fluorophenyl)methyl]-, (2S)-; Azido-Fluorobenzyl-Propanamide, (S)-isomer
EINECS	Contact for details

Quality Control

Every batch of (S)-3-Azido-2-(4-Fluorobenzyl)Propanamide is produced and tested under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable and consistent performance in your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.