Description

2-Fluorobenzo[B]Thiophen-3-Ylboronic Acid is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the discovery and production of novel active compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between the benzo[b]thiophene scaffold and various aryl/heteroaryl halides, essential for creating diverse chemical libraries.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate the fluorinated benzo[b]thiophene moiety.
• Material Science & OLED Development: Serves as a precursor for synthesizing novel organic semiconductors, charge-transport materials, and light-emitting molecules for electronic devices.
• Chemical Biology & Probe Development: Employed in creating fluorescent tags, molecular probes, and enzyme inhibitors for biochemical and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects at various scales.

Basic Information

Product Name	2-Fluorobenzo[B]Thiophen-3-Ylboronic Acid
CAS No.	916150-44-2
Molecular Formula	C8H6BFO2S
Molecular Weight	195.99 g/mol
Synonyms	(2-Fluorobenzo[b]thiophen-3-yl)boronic Acid; 2-Fluorobenzo[b]thiophene-3-boronic Acid; 2-Fluoro-1-benzothiophene-3-boronic Acid; 2-Fluoro-3-borono-1-benzothiophene; 2-Fluoro-benzo[b]thiophene-3-ylboronic Acid; B-(2-Fluorobenzo[b]thien-3-yl)boronic Acid; 916150-44-2
EINECS	Contact for details

Quality Control

Our 2-Fluorobenzo[B]Thiophen-3-Ylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specification results. Our quality commitment supports applications requiring material for GLP (Good Laboratory Practice) and cGMP (current Good Manufacturing Practice) environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.