Description

(S)-Piperazine-2-Carboxylic Acid, N1-Fmoc Protected Hydrochloride Hemihydrate 97% is a high-purity, chiral building block specifically engineered for advanced pharmaceutical synthesis and peptide research. This compound is critical for the controlled introduction of the (S)-piperazine-2-carboxylic acid moiety into complex molecular architectures, ensuring stereochemical integrity. It is an essential reagent for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), particularly in oncology, neurology, and antiviral therapeutic areas.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the sequential assembly of complex peptides and peptidomimetics.
• Pharmaceutical Intermediate: A crucial chiral precursor in the synthesis of small-molecule drug candidates targeting GPCRs, kinases, and other biological receptors.
• Combinatorial Chemistry: Used in the generation of diverse compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: Incorporated into the design of inhibitors where the piperazine scaffold is central to binding affinity.
• Bioconjugation & Linker Chemistry: Serves as a functionalized spacer or linker molecule in antibody-drug conjugates (ADCs) and other bioconjugates.
• Process Chemistry & Scale-Up: Provides a reliable, high-quality starting material for the GMP-compliant manufacturing of clinical trial materials and commercial APIs.

Basic Information

Product Name	(S)-Piperazine-2-Carboxylic Acid, N1-Fmoc Protected Hydrochloride Hemihydrate 97%
CAS No.	915707-72-1
Molecular Formula	C21H23N3O4 • HCl • 0.5H2O
Molecular Weight	424.89 g/mol (for the hemihydrate hydrochloride salt)
Synonyms	Fmoc-(S)-piperazine-2-carboxylic acid hydrochloride hemihydrate; (S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]piperazine-2-carboxylic acid hydrochloride hemihydrate; Fmoc-Pip(2-COOH)-OH • HCl • 0.5H2O; Nα-Fmoc-(S)-piperazine-2-carboxylic acid HCl salt hemihydrate; (2S)-1-(9-Fluorenylmethyloxycarbonyl)piperazine-2-carboxylic acid hydrochloride hydrate; Fmoc-L-Pip(2-COOH)-OH hydrochloride hemihydrate; N-Fmoc-L-piperazine-2-carboxylic acid hydrochloride hemihydrate
EINECS	Contact for details

Quality Control

Our (S)-Piperazine-2-Carboxylic Acid, N1-Fmoc Protected Hydrochloride Hemihydrate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	2.0 - 4.0% (Theoretical for hemihydrate: ~2.1%)
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.