Description

[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-(2-Nitro-Phenyl)-Acetic Acid is a specialized Fmoc-protected amino acid derivative, a key building block in modern solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the precise, sequential construction of complex peptides and peptidomimetics, particularly those requiring the incorporation of a modified phenylalanine residue. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors, where it is used to create novel therapeutic peptides, diagnostic agents, and biochemical probes. The CAS number for this compound is 915696-44-5.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid derivative for the automated or manual synthesis of custom peptide sequences.
• Pharmaceutical R&D: A critical intermediate in the development of peptide-based drugs targeting various diseases.
• Bioconjugation: Used to introduce specific functional handles or labels onto peptides for creating antibody-drug conjugates (ADCs) or imaging agents.
• Combinatorial Chemistry: Serves as a building block in libraries for high-throughput screening to discover new bioactive compounds.
• Academic Research: Employed in biochemistry and molecular biology labs to study protein-protein interactions and enzyme mechanisms using synthetic peptide substrates.
• Production of Non-Natural Amino Acids: Acts as a precursor for synthesizing more complex, tailor-made amino acid analogs.

Basic Information

Item	Detail
Product Name	[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-(2-Nitro-Phenyl)-Acetic Acid
CAS No.	915696-44-5
Molecular Formula	C23H18N2O6
Molecular Weight	418.40 g/mol
Synonyms	Fmoc-2-Nitrophenylalanine; Fmoc-2-NO2-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-nitro-L-phenylalanine; Nα-Fmoc-2-nitrophenylalanine; Fmoc-Phe(2-NO2)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(2-nitrophenyl)propanoic acid; N-Fmoc-2-nitro-L-phenylalanine
EINECS	Contact for details

Quality Control

Our [(9H-Fluoren-9-Ylmethoxycarbonylamino)]-(2-Nitro-Phenyl)-Acetic Acid is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.