Description

[4-Cyano-3-(Trifluoromethyl)Phenyl]Boronic Acid is a high-value organoboron building block characterized by its unique combination of a boronic acid functional group with cyano and trifluoromethyl substituents. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex biaryl and heterobiaryl structures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates, particularly those targeting CNS disorders, inflammation, and oncology, where the trifluoromethyl group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging the boronic acid group for efficient carbon-carbon bond formation in complex molecules.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials due to its aromatic core and reactive handles.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological processes, where the cyano group can serve as a spectroscopic handle or be further derivatized.
• Catalyst & Ligand Preparation: Useful for synthesizing novel ligands and catalysts for asymmetric synthesis and other transition metal-catalyzed transformations.

Basic Information

Product Name	[4-Cyano-3-(Trifluoromethyl)Phenyl]Boronic Acid
CAS No.	915299-32-0
Molecular Formula	C8H5BF3NO2
Molecular Weight	214.94 g/mol
Synonyms	4-Cyano-3-(trifluoromethyl)benzeneboronic acid; (4-Cyano-3-(trifluoromethyl)phenyl)boronic acid; B-[4-Cyano-3-(trifluoromethyl)phenyl]boronic acid; 3-Trifluoromethyl-4-cyanophenylboronic acid; 2-Cyano-5-boronobenzotrifluoride; 4-CN-3-CF3-PhB(OH)2; Boronic acid, B-[4-cyano-3-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Every batch of [4-Cyano-3-(Trifluoromethyl)Phenyl]Boronic Acid is manufactured and tested under strict quality management protocols to ensure consistency and reliability for critical synthetic applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.