Description

Ethyl-2,2-Difluoro-2-(3-Methoxyphenyl)Acetate is a specialized fluorinated building block of significant interest in advanced organic synthesis. This compound is valued for its unique difluoroacetate ester moiety attached to a methoxyphenyl ring, which imparts specific electronic and steric properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the construction of complex molecules, particularly those requiring the introduction of fluorine atoms to modulate bioactivity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and oncology.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the difluoroacetate group can enhance compound efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and advanced materials with tailored surface properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry for constructing sophisticated ligands that can modulate catalytic activity in asymmetric synthesis.
• Fluorine Chemistry Research: An essential reagent for academic and industrial laboratories exploring new C-F bond formation reactions and the study of fluorine effects in molecular design.
• Fine Chemical Manufacturing: Incorporated into the multi-step synthesis of complex fragrance and flavor compounds, dyes, and other high-value fine chemicals.

Basic Information

Product Name	Ethyl-2,2-Difluoro-2-(3-Methoxyphenyl)Acetate
CAS No.	915133-57-2
Molecular Formula	C11H12F2O3
Molecular Weight	230.21 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(3-methoxyphenyl)acetate; 2,2-Difluoro-2-(3-methoxyphenyl)acetic Acid Ethyl Ester; Ethyl α,α-Difluoro-3-methoxybenzeneacetate; 3-Methoxyphenyl(difluoro)acetic Acid Ethyl Ester; Ethyl (3-Methoxyphenyl)difluoroacetate; Difluoro(3-methoxyphenyl)acetic Acid Ethyl Ester; Ethyl 2,2-Difluoro-2-(m-methoxyphenyl)acetate; Acetic acid, 2,2-difluoro-2-(3-methoxyphenyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl-2,2-Difluoro-2-(3-Methoxyphenyl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.