Description

5-Thia-1-Azabicyclo[4.2.0]Oct-3-Ene-2-Carboxylic Acid, 7-[[(2Z)-2-(2-Amino-4-Thiazolyl)-2-(Methoxyimino)Acetyl]Amino]-3-(Methoxymethyl)-8-Oxo-, (6R,7R)- is a high-purity advanced pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. This compound is critical for the synthesis of next-generation β-lactam antibiotics, offering a key structural component for enhanced antimicrobial activity. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of potent antibacterial agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Core intermediate for manufacturing advanced cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies for novel antibacterial drug candidates.
• Antibiotic Production: Key building block in the chemical synthesis of broad-spectrum antibiotics targeting resistant pathogens.
• Process Chemistry & Scale-Up: Serves as a critical starting material for process optimization and commercial-scale manufacturing.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	5-Thia-1-Azabicyclo[4.2.0]Oct-3-Ene-2-Carboxylic Acid, 7-[[(2Z)-2-(2-Amino-4-Thiazolyl)-2-(Methoxyimino)Acetyl]Amino]-3-(Methoxymethyl)-8-Oxo-, (6R,7R)-
CAS No.	914914-59-3
Molecular Formula	C15H19N5O6S2
Molecular Weight	437.47 g/mol
Synonyms	(6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cefotaxime Impurity; Cefotaxime Intermediate; 7-ACA Derivative; 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, (6R,7R)-; Cephalosporin C-7 Side Chain Intermediate
EINECS	Contact for details

Quality Control

Our 5-Thia-1-Azabicyclo[4.2.0]Oct-3-Ene-2-Carboxylic Acid derivative is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and stereochemical integrity suitable for pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support GMP and regulatory compliance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.