Description

Angiotensinogen (1-12) (Mouse, Rat) CAS NO 914910-73-9 is a specific peptide fragment derived from the angiotensinogen protein, which plays a critical role in the renin-angiotensin system (RAS) regulating blood pressure and fluid balance. This high-purity reference standard is essential for precise biochemical and pharmacological research, enabling accurate calibration and validation in experimental assays. It is primarily utilized by researchers and scientists in the fields of cardiovascular disease research, hypertension studies, and pharmaceutical development for drug discovery and mechanism-of-action investigations.

Application

• Biochemical Research: Used as a critical reference standard and substrate in studies of the renin-angiotensin-aldosterone system (RAAS).
• Cardiovascular Disease Modeling: Essential for in vitro and in vivo research focused on hypertension, heart failure, and renal function.
• Pharmaceutical Development: Serves as a key reagent in high-throughput screening (HTS) assays for the discovery of novel antihypertensive drugs and RAS inhibitors.
• Enzyme Kinetics Studies: Employed to study the enzymatic activity and specificity of renin and other proteases involved in angiotensin peptide generation.
• Immunoassay Development: Used as a calibrator or antigen in the development and validation of ELISA and other immunoassays targeting angiotensinogen pathways.
• Academic & Institutional Research: A fundamental tool for universities and research institutes conducting basic science on blood pressure regulation and hormonal systems.

Basic Information

Product Name	Angiotensinogen (1-12) (Mouse, Rat)
CAS No.	914910-73-9
Molecular Formula	C58H89N17O17S
Molecular Weight	1320.5 g/mol
Synonyms	Angiotensinogen Fragment 1-12; Mouse/Rat Angiotensinogen (1-12); Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile; DRVYIHPFHLVI; Angiotensin I Precursor (1-12); Angiotensinogen Peptide (1-12); Rat Angiotensinogen Residues 1-12
EINECS	Contact for details

Quality Control

Every batch of Angiotensinogen (1-12) (Mouse, Rat) is manufactured under stringent conditions and undergoes comprehensive analytical testing to ensure the highest standards of identity, purity, and consistency. Our quality commitment includes rigorous analysis by HPLC and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, peptide content, and other critical specifications to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Conforms to theoretical composition
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.