Description

3-Fluoro-5-Methoxyphenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both electron-donating methoxy and electron-withdrawing fluoro and nitrile groups, makes it a valuable precursor for constructing complex pharmacophores and agrochemical intermediates. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores in electronic materials for displays and lighting applications.
• Functional Polymer Monomer: Employed in the synthesis of specialty polymers with tailored properties such as thermal stability, chemical resistance, and specific optical characteristics.
• Cross-Coupling Reactions: The aromatic ring is amenable to various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for creating diverse biaryl structures.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	3-Fluoro-5-Methoxyphenylacetonitrile
CAS No.	914637-31-3
Molecular Formula	C9H8FNO
Molecular Weight	165.16 g/mol
Synonyms	(3-Fluoro-5-methoxyphenyl)acetonitrile; 2-(3-Fluoro-5-methoxyphenyl)acetonitrile; 3-Fluoro-5-methoxybenzyl cyanide; 3-Fluoro-5-methoxybenzeneacetonitrile; 914637-31-3; 3-Fluoro-5-methoxy phenylacetonitrile; 3-Fluoro-5-methoxybenzenecetonitrile
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-Methoxyphenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, open flames, and strong oxidizing agents. Due to its light-sensitive nature, containers should be amber or otherwise opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.