Description

2H-2-Ethyl Candesartan Cilexetil is a deuterated isotopologue of the active pharmaceutical ingredient candesartan cilexetil, a potent angiotensin II receptor blocker (ARB). This compound is a critical stable isotope-labeled standard used in analytical research and development to ensure accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug metabolism and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical reference compound in quantitative bioanalysis for accurate measurement of candesartan and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to trace and quantify the metabolic pathways and pharmacokinetic profiles of the parent drug in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Essential for developing robust, sensitive, and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Stable Isotope Dilution Assays: Employed in high-precision assays to minimize matrix effects and improve analytical accuracy.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradants during API manufacturing.
• Academic and Industrial Research: Supports fundamental research in cardiovascular pharmacology and analytical chemistry techniques.

Basic Information

Product Name	2H-2-Ethyl Candesartan Cilexetil
CAS No.	914613-36-8
Molecular Formula	C33H32D2N6O6
Molecular Weight	612.68 g/mol (for C33H32D2N6O6)
Synonyms	Candesartan Cilexetil-d2 (2-Ethyl-d2); (2-Ethyl-d2)-Candesartan Cilexetil; 2H-2-Ethyl Candesartan Cilexetil; Deuterated Candesartan Cilexetil; Candesartan-d2 Cilexetil; (±)-1-Hydroxyethyl 2-ethoxy-1-[[2'-(2H5-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate (deuterated form); TC-Candesartan-d2; AT1 receptor antagonist deuterated standard.
EINECS	Contact for details

Quality Control

Every batch of our 2H-2-Ethyl Candesartan Cilexetil is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical reference standards. Comprehensive testing includes identity confirmation, assay, isotopic enrichment, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.