Description

Fmoc-Ser(Me,Ac4Neu5Acα2-6Ac2Galnacα)-Oh is a sophisticated, protected glycoamino acid building block designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for the precise and efficient chemical synthesis of glycopeptides, which are essential for studying protein-glycan interactions and developing novel biotherapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in glycobiology, vaccine development, and the creation of complex peptide-based drugs.

Application

• Glycopeptide Synthesis: A key protected intermediate for the automated solid-phase synthesis of O-linked glycopeptides, enabling the study of glycosylation effects.
• Glycobiology Research: Used to incorporate specific, complex sialylated glycan structures into peptide backbones for interaction and binding studies.
• Pharmaceutical R&D: Serves as a building block in the development of synthetic glycoprotein mimics, peptide vaccines, and targeted therapeutics.
• Bioconjugation: Facilitates the site-specific attachment of complex carbohydrate motifs to peptides or other biomolecules.
• Chemical Biology Tool Development: Enables the creation of probes and inhibitors to study glycosyltransferase enzymes and glycan-mediated signaling pathways.
• Standards and Reference Materials: Provides a high-purity standard for analytical method development and quality control in glycopeptide production.

Basic Information

Product Name	Fmoc-Ser(Me,Ac4Neu5Acα2-6Ac2Galnacα)-Oh
CAS No.	914456-67-0
Molecular Formula	C₅₈H₇₇N₅O₂₈
Molecular Weight	1280.25 g/mol
Synonyms	Fmoc-Ser(Ac₃-α-D-Neu5Ac-(2→6)-α-D-GalNAc)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-[5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosylonic acid-(2→6)-2-acetamido-2-deoxy-α-D-galactopyranosyl]-L-serine; Fmoc-Ser(Ac₄Neu5Acα2-6GalNAcα)-OH; Fmoc-Ser(GalNAc(α1-)[Neu5Ac(α2-6)])-OH (protected); Glycoamino Acid Building Block; Fmoc-Ser(Ac3Neu5Acα2-6AcGalNAcα)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Ser(Me,Ac4Neu5Acα2-6Ac2Galnacα)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided, documenting purity, identity, and other critical parameters to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry atmosphere before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.