Description

Fmoc-Pip(Alloc)-Oh is a protected amino acid derivative widely used in solid-phase peptide synthesis (SPPS). This compound is critical for introducing the pipecolic acid (Pip) residue with orthogonal protecting groups, enabling complex and sequential peptide assembly. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, specifically for incorporating the non-proteinogenic amino acid L-pipecolic acid into peptide chains.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of novel peptide drugs, including hormone analogs, enzyme inhibitors, and antimicrobial peptides.
• Combinatorial Chemistry: Used in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Bioconjugation: The Alloc (allyloxycarbonyl) protecting group allows for selective deprotection under mild, orthogonal conditions, facilitating site-specific modifications and labeling of peptides.
• Academic & Industrial Research: Employed in biochemical and structural biology studies to investigate protein-protein interactions and enzyme mechanisms using synthetic peptide probes.

Basic Information

Product Name	Fmoc-Pip(Alloc)-Oh
CAS No.	914358-24-0
Molecular Formula	C26H29NO6
Molecular Weight	451.52 g/mol
Synonyms	Fmoc-L-pipecolic acid(Alloc)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(allyloxycarbonyl)-L-pipecolic Acid; Fmoc-Pip(Alloc)-OH; Fmoc-Pip(Alloc); (2S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(allyloxycarbonyl)piperidine-2-carboxylic acid; N-α-Fmoc-N-δ-Alloc-L-pipecolic Acid; Fmoc-Pip(Alloc)-OH CAS 914358-24-0; N-Fmoc-N'-Alloc-L-pipecolic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-Pip(Alloc)-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like pharmaceutical R&D. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.