Description

Rel-1-(9H-Fluoren-9-Ylmethyl) (3R,5R)-5-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-1,3-Piperidinedicarboxylate is a sophisticated chiral piperidine derivative, serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in providing a protected, stereochemically defined amino acid scaffold essential for constructing complex bioactive molecules. This high-purity intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in peptide-mimetic and protease inhibitor programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Peptidomimetic Chemistry: Used to construct non-peptide scaffolds that mimic the structure and function of natural peptides for drug discovery.
• Protease Inhibitor Synthesis: Serves as a core structural component in the synthesis of inhibitors targeting specific proteolytic enzymes.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce defined chiral centers into complex molecular architectures.
• Medicinal Chemistry Research: Utilized in lead optimization and structure-activity relationship (SAR) studies for various disease targets.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and clinical trial materials.

Basic Information

Product Name	Rel-1-(9H-Fluoren-9-Ylmethyl) (3R,5R)-5-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-1,3-Piperidinedicarboxylate
CAS No.	914260-23-4
Molecular Formula	C27H30N2O6
Molecular Weight	478.54 g/mol
Synonyms	(3R,5R)-1-[(9H-Fluoren-9-yl)methyl] 5-[(tert-butoxycarbonyl)amino]piperidine-1,3-dicarboxylate; 1-Fmoc-3-Cbz-5-N-Boc-cis-3,5-diaminopiperidine; (3R,5R)-1-(Fmoc)-3-(Cbz)-5-(Boc-NH)-piperidine; 5-[(tert-Butoxycarbonyl)amino]-1,3-piperidinedicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester; Fmoc-3-Cbz-5-N-Boc-3,5-diaminopiperidine; cis-Fmoc-Cbz-Boc-DADP; Boc-DADP(Fmoc,Cbz); 914260-23-4
EINECS	Contact for details

Quality Control

Our Rel-1-(9H-Fluoren-9-Ylmethyl) (3R,5R)-5-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-1,3-Piperidinedicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.