Description

2-(4-Amino-2-Fluorophenyl) Acetic Acid is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its bifunctional nature, featuring both a reactive amino group and a carboxylic acid moiety on a fluorinated benzene ring, enabling its use in constructing complex molecular architectures. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used to develop novel herbicides and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics and Bio-conjugation: The carboxylic acid group allows for coupling to peptides or other biomolecules, useful in creating targeted probes and conjugates.
• Material Science Research: Employed in the development of advanced polymers and functional materials with specific electronic or surface properties.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-(4-Amino-2-Fluorophenyl) Acetic Acid
CAS No.	914224-31-0
Molecular Formula	C8H8FNO2
Molecular Weight	169.15 g/mol
Synonyms	2-Fluoro-4-aminophenylacetic Acid; (4-Amino-2-fluorophenyl)acetic Acid; 2-Fluoro-4-aminobenzeneacetic Acid; 4-Amino-2-fluorobenzenacetic Acid; 2-(4-Amino-2-fluorophenyl)ethanoic Acid; 4-Amino-2-fluoro-α-toluic Acid; 2-Fluoro-4-aminohydrocinnamic Acid (deprecated); AA-2FPA (abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Amino-2-Fluorophenyl) Acetic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We ensure compliance with exacting standards suitable for research and commercial synthesis. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.