Description

(S)-(+)-[(R)-2-Dicyclohexylphosphinoferrocenyl](N,n-Dimethylamino)(2-Dicyclohexylphosphinophenyl)Methane is a highly sophisticated, chiral ferrocenyl phosphine ligand designed for asymmetric catalysis. This compound matters because it provides exceptional enantioselectivity and catalytic activity in critical carbon-carbon and carbon-heteroatom bond-forming reactions, enabling the synthesis of complex chiral molecules. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-performance, tunable catalysts for developing new active ingredients and advanced materials.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for producing single-enantiomer pharmaceutical intermediates.
• Cross-Coupling Reactions: Facilitates challenging asymmetric Suzuki-Miyaura, Buchwald-Hartwig, and other palladium-catalyzed cross-couplings with high efficiency.
• Asymmetric Allylic Substitution: Enables the construction of stereogenic centers via Tsuji-Trost and related reactions for complex molecule synthesis.
• Pharmaceutical R&D: Key tool in the discovery and process development of chiral drugs, including APIs for oncology, CNS disorders, and cardiovascular diseases.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Manufacturing: Applied in the synthesis of high-value chiral flavors, fragrances, and specialty chemicals.
• Academic and Industrial Catalysis Research: Serves as a benchmark ligand for developing new catalytic methodologies and exploring novel reaction spaces.

Basic Information

Item	Details
Product Name	(S)-(+)-[(R)-2-Dicyclohexylphosphinoferrocenyl](N,n-Dimethylamino)(2-Dicyclohexylphosphinophenyl)Methane
CAS No.	914089-00-2
Molecular Formula	C47H63FeNP2
Molecular Weight	759.78 g/mol
Synonyms	(S)-(R)-JOSIPHOS SL-J009-1; (S)-(R)-JOSIPHOS SL-J009-1 Ligand; (S)-(R)-JOSIPHOS; (S,R)-JOSIPHOS; (S)-(R)-2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)ferrocene; (S)-(R)-1-[(R)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldicyclohexylphosphine; (S)-(R)-[1-[2-(Dicyclohexylphosphino)ferrocenyl]ethyl]dicyclohexylphosphine; SL-J009-1
EINECS	Contact for details

Quality Control

Our production of (S)-(+)-[(R)-2-Dicyclohexylphosphinoferrocenyl](N,n-Dimethylamino)(2-Dicyclohexylphosphinophenyl)Methane adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analysis, including HPLC for purity, NMR for structural confirmation, and chiral analysis to verify enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (Toluene, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.