Description

(S)-1-(2-Aminoacetyl)-Pyrrolidine-2-Carbonitrile is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound matters for its critical role in the synthesis of complex, biologically active molecules, particularly in the development of new therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery and process chemistry for targets such as protease inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: Used in the construction of scaffolds for inhibitors targeting various proteases.
• Peptidomimetic Chemistry: Serves as a constrained proline analog for creating peptide-like molecules with enhanced metabolic stability.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization campaigns.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective chemical transformations.
• Contract Manufacturing: Supplied to CDMOs for the scale-up and cGMP production of clinical trial materials.

Basic Information

Product Name	(S)-1-(2-Aminoacetyl)-Pyrrolidine-2-Carbonitrile
CAS No.	914070-99-8
Molecular Formula	C7H11N3O
Molecular Weight	153.18 g/mol
Synonyms	(2S)-1-(2-Aminoacetyl)pyrrolidine-2-carbonitrile; (S)-1-(Aminoacetyl)-2-pyrrolidinecarbonitrile; 2-Pyrrolidinecarbonitrile, 1-(2-aminoacetyl)-, (2S)-; L-Prolinenitrile, 1-(aminoacetyl)-; 1-(2-Aminoacetyl)-(S)-pyrrolidine-2-carbonitrile; (S)-2-Cyano-1-(2-aminoacetyl)pyrrolidine; (S)-Pyrrolidine-2-carbonitrile, 1-(2-aminoacetyl)-
EINECS	Contact for details

Quality Control

Our (S)-1-(2-Aminoacetyl)-Pyrrolidine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.