Description

4-Iodo-2-Cyanopyridine is a versatile halogenated heterocyclic building block of significant importance in modern synthetic chemistry. Its molecular structure, featuring both an iodine substituent and a cyano group on the pyridine ring, makes it a valuable precursor for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and as a key intermediate in active ingredient synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its reactivity for creating diverse heterocyclic scaffolds.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings, enabling rapid diversification of molecular libraries.
• Ligand and Catalyst Development: Utilized to synthesize novel pyridine-based ligands for transition metal catalysts used in asymmetric synthesis and industrial processes.
• Chemical Biology Probes: Acts as a starting point for creating tagged molecules or probes used to study biological pathways and protein interactions.

Basic Information

Product Name	4-Iodo-2-Cyanopyridine
CAS No.	913836-19-8
Molecular Formula	C6H3IN2
Molecular Weight	230.01 g/mol
Synonyms	2-Cyano-4-iodopyridine; 4-Iodopyridine-2-carbonitrile; 4-Iodo-2-pyridinecarbonitrile; 2-Pyridinecarbonitrile, 4-iodo-; 913836-19-8
EINECS	Contact for details

Quality Control

Our 4-Iodo-2-Cyanopyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.