Description

4-(2-Trifluoromethylphenylcarbamoyl)Phenylboronic Acid is a specialized boronic acid derivative featuring a trifluoromethylphenylcarbamoyl substituent. This compound is a high-value synthetic intermediate prized for its role in cross-coupling reactions, particularly the Suzuki-Miyaura reaction, enabling the construction of complex biaryl structures. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in advanced materials science for creating functional organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing biaryl motifs and fluorine atoms for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the Suzuki coupling to introduce complex aromatic groups.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors, where precise molecular architecture is critical.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and inhibitors for studying biological pathways and enzyme functions.
• Cross-Coupling Reactions: Primarily employed as a boronic acid coupling partner in palladium-catalyzed Suzuki-Miyaura reactions to form carbon-carbon bonds under mild conditions.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies and CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	4-(2-Trifluoromethylphenylcarbamoyl)Phenylboronic Acid
CAS No.	913835-42-4
Molecular Formula	C14H11BF3NO3
Molecular Weight	309.05 g/mol
Synonyms	[4-[(2-Trifluoromethylphenyl)carbamoyl]phenyl]boronic acid; 4-(2-Trifluoromethylbenzamido)phenylboronic acid; 4-[(2-Trifluoromethylphenyl)carbamoyl]benzeneboronic acid; B-[4-[[(2-Trifluoromethyl)phenyl]aminocarbonyl]phenyl]boronic acid; 4-Carbamoylphenylboronic acid, 2-trifluoromethyl derivative; 913835-42-4; Boronic acid, B-[4-[[(2-(trifluoromethyl)phenyl)amino]carbonyl]phenyl]-
EINECS	Contact for details

Quality Control

Our 4-(2-Trifluoromethylphenylcarbamoyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.