Description

Oxazole,2-[(1S)-7'-[Bis(3,5-Dimethylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Inden]-7-Yl]-4,5-Dihydro-4-(Phenylmethyl)-,(4S)- is a sophisticated, chiral phosphine-oxazole hybrid ligand designed for advanced catalytic applications. This compound matters because it provides exceptional stereoselectivity and activity in asymmetric synthesis, enabling the production of high-value, enantiomerically pure intermediates. It is critically needed by research institutions and pharmaceutical manufacturers developing novel active pharmaceutical ingredients (APIs) and fine chemicals where precise chiral control is paramount.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical synthesis.
• Cross-Coupling Reactions: Employed in palladium-catalyzed reactions such as Suzuki-Miyaura and Buchwald-Hartwig aminations for constructing complex molecular architectures.
• Asymmetric Allylic Alkylation: Facilitates the creation of carbon-carbon bonds with high enantiomeric excess for chiral building blocks.
• Hydroformylation: Used in the development of regioselective and enantioselective hydroformylation catalysts for specialty chemicals.
• Academic & Process Chemistry Research: A valuable tool for developing new catalytic methodologies and optimizing synthetic routes in R&D laboratories.
• Agrochemical Intermediate Synthesis: Applied in the asymmetric synthesis of chiral active ingredients for crop protection agents.

Basic Information

Item	Details
Product Name	Oxazole,2-[(1S)-7'-[Bis(3,5-Dimethylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Inden]-7-Yl]-4,5-Dihydro-4-(Phenylmethyl)-,(4S)-
CAS No.	913829-90-0
Molecular Formula	C52H48NOP
Molecular Weight	733.92 g/mol
Synonyms	(S)-2-[(S)-7'-[Bis(3,5-dimethylphenyl)phosphino]-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-inden]-7-yl]-4,5-dihydro-4-(phenylmethyl)oxazole; (S,S)-SPRIX-PHOS; SPIROX-P; Spirobiindane-based phosphino-oxazoline ligand; Chiral PHOX ligand derivative; Asymmetric hydrogenation ligand 913829-90-0; Ligand for enantioselective catalysis
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced under strict quality control protocols to ensure consistency and performance in sensitive catalytic applications. We employ advanced analytical techniques including HPLC, NMR, and chiral analysis to verify chemical identity, enantiomeric purity, and overall assay. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (ee%), and residual solvent levels is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light may degrade performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.