Description

(S)-(-)-7-[4(S)-(Benzyl)Oxazol-2-Yl]-7-Diphenylphosphino-2,23,3Tetrahydro-1,1'-Spiroiindane, Min. 97% (Sa,S)-Ph-Bn-Siphox is a high-purity, chiral phosphine-oxazoline hybrid ligand, a critical class of organocatalysts in asymmetric synthesis. Its value lies in enabling highly enantioselective transformations, crucial for producing single-isomer pharmaceutical intermediates and fine chemicals. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control. Supplied at a minimum purity of 97%, it ensures reliable and reproducible catalytic performance.

Application

This chiral ligand is designed for sophisticated catalytic applications where stereoselectivity is paramount. Key uses include:

• Asymmetric Hydrogenation: Catalyzing the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Serving as a key catalyst component in the synthesis of active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee).
• Cross-Coupling Reactions: Facilitating asymmetric versions of Suzuki, Heck, and other C-C bond-forming reactions.
• Agrochemical Production: Enabling the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for developing new asymmetric methodologies and exploring novel reaction pathways.
• Fine Chemical Manufacturing: Production of specialty flavors, fragrances, and electronic chemicals where chirality impacts function.

Basic Information

Product Name	(S)-(-)-7-[4(S)-(Benzyl)Oxazol-2-Yl]-7-Diphenylphosphino-2,23,3Tetrahydro-1,1'-Spiroiindane, Min. 97% (Sa,S)-Ph-Bn-Siphox
CAS No.	913829-88-6
Molecular Formula	C39H34NOP
Molecular Weight	563.67 g/mol
Synonyms	(Sa,S)-Ph-Bn-SIPHOX; (S)-(-)-7-[4(S)-(Benzyl)-2-oxazolinyl]-7-diphenylphosphino-2,2,3,3-tetrahydro-1,1'-spirobi[indane]; (S)-(-)-7-[4(S)-(Benzyl)Oxazol-2-Yl]-7-Diphenylphosphino-2,2,3,3-Tetrahydro-1,1'-Spirobiindane; Ph-Bn-SIPHOX Ligand; SIPHOX Ligand; Chiral Spiro Phosphine-Oxazoline Ligand; Asymmetric Hydrogenation Ligand; (S,S)-Ph-Bn-SIPHOX (common alternate notation)
EINECS	Contact for details

Quality Control

Our production of this advanced chiral ligand adheres to stringent quality protocols to guarantee batch-to-batch consistency and catalytic efficacy. Every lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. For customers with specific purity or packaging requirements, custom synthesis and specialized QC testing are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain catalytic activity. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 97%
Chiral Purity (Chiral HPLC)	Min. 99% ee
Water Content (KF)	Max. 0.5%
Residue on Ignition	Max. 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.