Description

Brexpiprazole (3,4)-Dihydro-2(1H)-Quinolinone is a key pharmaceutical intermediate in the synthesis of the active pharmaceutical ingredient Brexpiprazole. This compound matters for its critical role in the production of a major atypical antipsychotic medication, ensuring the structural integrity and efficacy of the final drug product. It is primarily needed by pharmaceutical manufacturers, research institutions, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development and production of central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a crucial building block in the multi-step synthesis of Brexpiprazole API.
• Research & Development: Used in process chemistry research, route scouting, and optimization for new synthetic pathways.
• Reference Standard: Serves as a high-purity standard for analytical method development and validation (HPLC, LC-MS) in quality control laboratories.
• Pre-clinical Studies: Employed in the preparation of derivatives or analogs for structure-activity relationship (SAR) studies.
• GMP Manufacturing: Supplied under controlled conditions for use in cGMP (Current Good Manufacturing Practice) production of the final drug substance.

Basic Information

Product Name	Brexpiprazole (3,4)-Dihydro-2(1H)-Quinolinone
CAS No.	913612-07-4
Molecular Formula	C19H20N2O2
Molecular Weight	308.38 g/mol
Synonyms	7-{4-[4-(1-Benzothiophen-4-yl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one; 7-[4-[4-(1-Benzothiophen-4-yl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone; OPC-34712 Dihydroquinolinone Intermediate; Brexpiprazole Dihydroquinolinone; Brexpiprazole Key Intermediate; 4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy-3,4-dihydroquinolin-2(1H)-one
EINECS	Contact for details

Quality Control

Our Brexpiprazole (3,4)-Dihydro-2(1H)-Quinolinone is produced and tested to meet stringent quality standards suitable for pharmaceutical R&D and manufacturing. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, identification by spectroscopic methods (IR, NMR), and control of specified impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and compliance with your internal specifications and regulatory expectations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.