Description

3-Demethyl Colchicine 3-o-β-D-Glucuronide is a specific glucuronide metabolite of colchicine, a well-known alkaloid with significant pharmacological activity. This high-purity reference standard is critical for advanced pharmaceutical research and development, particularly in metabolism and pharmacokinetic studies. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in drug discovery and bioanalytical method development.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification and qualification of colchicine and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, bioavailability, and excretion profiles of colchicine-based therapeutics.
• Bioanalytical Method Development: Used to develop and validate sensitive analytical methods, such as LC-MS/MS, for therapeutic drug monitoring and clinical research.
• Toxicological Research: Employed in studies to understand the safety profile and metabolite-related effects of colchicine administration.
• Impurity Profiling: Acts as a known impurity or degradation product standard in the quality control of colchicine Active Pharmaceutical Ingredients (APIs) and finished dosage forms.

Basic Information

Product Name	3-Demethyl Colchicine 3-o-β-D-Glucuronide
CAS No.	913079-71-7
Molecular Formula	C28H33NO12
Molecular Weight	575.56 g/mol
Synonyms	Colchicine 3-O-β-D-Glucuronide (Demethylated); N-Desmethylcolchicine Glucuronide; 3-Demethylcolchicine Glucuronide; Colchicoside Metabolite; 3-O-(β-D-Glucopyranosyluronic acid)-N-desacetyl-N-deformylcolchicine; 10-Demethylcolchicine 3-glucuronide; Colchicine Metabolite M2
EINECS	Contact for details

Quality Control

Our 3-Demethyl Colchicine 3-o-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical reference materials. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.