Description

2-Ethynyl-4-Fluoro-1-Methoxybenzene is a high-purity fluorinated aromatic building block featuring both an ethynyl and a methoxy functional group. This compound is valued for its role as a versatile intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought after by researchers and manufacturers in the pharmaceutical and agrochemical industries for applications in drug discovery and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: The ethynyl group makes it an excellent substrate for Sonogashira, Click chemistry, and other palladium-catalyzed cross-coupling reactions.
• Ligand and Catalyst Development: Employed in the synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in aromatic systems.

Basic Information

Product Name	2-Ethynyl-4-Fluoro-1-Methoxybenzene
CAS No.	912971-79-0
Molecular Formula	C9H7FO
Molecular Weight	150.15 g/mol
Synonyms	4-Fluoro-2-ethynylanisole; 1-Ethynyl-4-fluoro-2-methoxybenzene; 2-Ethynyl-4-fluoroanisole; 4-Fluoro-2-(ethynyl)anisole; 2-Methoxy-5-fluorophenylacetylene
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-4-Fluoro-1-Methoxybenzene is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.