Description

cis-3-Amino-2-Methyl-n-Cbz-Piperidine is a high-purity, protected piperidine derivative featuring both a primary amine and a carboxybenzyl (Cbz) protecting group. This compound is a critical chiral building block and advanced pharmaceutical intermediate, enabling the synthesis of complex molecules with precise stereochemistry. It is essential for research and development in medicinal chemistry, particularly for targeting central nervous system (CNS) disorders and other therapeutic areas. Our supply ensures consistent quality and reliable availability for global pharmaceutical and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in neurological and psychiatric drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new bioactive molecules.
• Peptidomimetic Synthesis: Serves as a constrained scaffold for designing peptide analogs and protease inhibitors.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in catalytic asymmetric transformations to introduce stereogenic centers.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds for studying enzyme function and receptor interactions.
• Custom Synthesis & Contract Manufacturing: A starting material for the custom production of complex, high-value specialty chemicals.

Basic Information

Product Name	cis-3-Amino-2-Methyl-n-Cbz-Piperidine
CAS No.	912451-60-6
Molecular Formula	C15H22N2O2
Molecular Weight	262.35 g/mol
Synonyms	(2R,3S)-1-[(Benzyloxy)carbonyl]-2-methylpiperidine-3-amine; (3S,2R)-1-Cbz-2-methyl-3-aminopiperidine; 1-N-Cbz-cis-3-amino-2-methylpiperidine; 1-Carbobenzoxy-cis-3-amino-2-methylpiperidine; 1-(Benzyloxycarbonyl)-cis-3-amino-2-methylpiperidine; 1-N-Cbz-2-methyl-3-aminopiperidine; cis-3-Amino-2-methyl-1-N-Cbz-piperidine; 1-Cbz-2-methylpiperidin-3-amine
EINECS	Contact for details

Quality Control

Every batch of cis-3-Amino-2-Methyl-n-Cbz-Piperidine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity compliant with industry standards for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.