Description

(7-Fluoro-1H-Indol-2-Yl)Boronic Acid Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry. This compound matters as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex fluorinated indole derivatives. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical synthon for constructing fluorinated indole scaffolds in drug discovery programs, particularly for kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides that incorporate the 7-fluoroindole moiety for enhanced bioactivity.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as OLED emitters and charge-transport layers, where fluorination tunes electronic properties.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a boronic ester coupling partner with aryl/heteroaryl halides to form biaryl and heterobiaryl bonds under palladium catalysis.
• Chemical Biology & Probe Development: Utilized in synthesizing fluorescent probes and activity-based protein profiling (ABPP) agents that target specific enzymes or biological pathways.
• Library Synthesis for High-Throughput Screening: Enables the rapid, parallel synthesis of diverse compound libraries for biological screening in lead identification.

Basic Information

Product Name	(7-Fluoro-1H-Indol-2-Yl)Boronic Acid Pinacol Ester
CAS No.	912331-75-0
Molecular Formula	C14H17BFNO2
Molecular Weight	261.10 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-7-fluoro-1H-indole; 7-Fluoro-1H-indole-2-boronic acid pinacol ester; 7-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; (7-Fluoro-2-indolyl)boronic acid pinacol ester; B-(7-Fluoro-1H-indol-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 7-Fluoroindole-2-boronic acid pinacol ester; 912331-75-0
EINECS	Contact for details

Quality Control

Our (7-Fluoro-1H-Indol-2-Yl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full analytical data are provided to guarantee supply consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.