Description

Moc-Norleucine CAS NO 911481-41-9 is a protected amino acid derivative, specifically the methoxycarbonyl (Moc) derivative of norleucine. This compound is a crucial building block in modern peptide synthesis and medicinal chemistry, offering enhanced stability and controlled reactivity during complex chemical transformations. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for the development of novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key intermediate for the controlled incorporation of norleucine residues into peptide chains, particularly in Fmoc/t-Bu strategies.
• Medicinal Chemistry Research: Used in the design and synthesis of peptide-based drug candidates, enzyme inhibitors, and receptor ligands where structural modification is required.
• Bioconjugation: Acts as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Proteomics & Biochemistry: Employed as a stable, non-natural amino acid analog in metabolic labeling studies and protein engineering.
• Fine Chemical Synthesis: A versatile chiral synthon for the asymmetric synthesis of more complex organic molecules and natural product analogs.

Basic Information

Product Name	Moc-Norleucine
CAS No.	911481-41-9
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	N-Methoxycarbonylnorleucine; (S)-2-((Methoxycarbonyl)amino)hexanoic Acid; N-Moc-L-Norleucine; L-Norleucine, N-[(methoxycarbonyl)]-; N-Carbomethoxynorleucine; 2-[(Methoxycarbonyl)amino]hexanoic acid; (2S)-2-(Methoxycarbonylamino)hexanoic acid; Moc-Nle-OH
EINECS	Contact for details

Quality Control

Our Moc-Norleucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (by HPLC), and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.