Description

(R)-3,3'-Bis(Diphenylphosphanyl)-[1,1'-Binapthalene]-2,2'-Diol is a high-value, chiral diphosphine ligand widely recognized for its pivotal role in asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, which are critical for the efficient and cost-effective synthesis of single-enantiomer pharmaceutical intermediates and fine chemicals. This product is essential for research and development scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, a key step in active pharmaceutical ingredient (API) manufacturing.
• Asymmetric C-C Bond Formation: Catalyzes critical reactions like Rh-catalyzed conjugate additions and Pd-catalyzed cross-couplings with high enantiomeric excess.
• Pharmaceutical Intermediate Synthesis: Used in the production of chiral drugs for cardiovascular, central nervous system, and metabolic disease treatments.
• Agrochemical Synthesis: Enables the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Process Development & Scale-up: Employed in optimizing and scaling laboratory-scale enantioselective reactions to commercial production.
• Academic & Industrial Research: A fundamental tool for developing new catalytic methodologies and exploring novel chiral space in synthetic chemistry.

Basic Information

Product Name	(R)-3,3'-Bis(Diphenylphosphanyl)-[1,1'-Binapthalene]-2,2'-Diol
CAS No.	911383-51-2
Molecular Formula	C44H32O2P2
Molecular Weight	662.67 g/mol
Synonyms	(R)-BINAP; (R)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl; (R)-(+)-BINAP; (R)-(+)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl; (R)-1,1'-Binaphthalene-2,2'-diylbis(diphenylphosphine); (R)-BINAP ligand; (R)-BINAP(O); (R)-(+)-5,5'-Bis(diphenylphosphino)-1,1'-binaphthyl
EINECS	Contact for details

Quality Control

Our (R)-BINAP is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analytical characterization, including HPLC for chiral purity and 31P NMR for chemical identity and ligand integrity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key specifications such as enantiomeric excess and chemical purity. Our quality system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized; prolonged exposure to air or moisture should be avoided. Allow the container to reach room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (31P NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.