Description

(S)-tert-Butyl 2-(Hydroxymethyl)-1,4-Oxazepane-4-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is valued for its role in the synthesis of complex bioactive molecules, particularly in medicinal chemistry and drug discovery. It is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries who require high-quality, stereochemically defined intermediates for API development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapeutics.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the oxazepane scaffold into novel drug candidates.
• Asymmetric Synthesis: Serves as a valuable precursor for the construction of complex, enantiomerically pure molecules in organic synthesis.
• Peptidomimetics Research: Employed in the design and synthesis of peptidomimetic compounds, where the 1,4-oxazepane ring acts as a constrained surrogate for peptide bonds or amino acid residues.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific chiral intermediate.

Basic Information

Product Name	(S)-tert-Butyl 2-(Hydroxymethyl)-1,4-Oxazepane-4-Carboxylate
CAS No.	911223-02-4
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	1,4-Oxazepane-4-carboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S)-; tert-Butyl (2S)-2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate; (S)-2-(Hydroxymethyl)-1,4-oxazepane-4-carboxylic acid tert-butyl ester; (S)-tert-Butyl 2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate; (S)-Boc-2-(hydroxymethyl)-1,4-oxazepane; (S)-1,4-Oxazepane-2-methanol, 4-(1,1-dimethylethoxy)carbonyl-; (S)-4-(tert-Butoxycarbonyl)-1,4-oxazepane-2-methanol
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 2-(Hydroxymethyl)-1,4-Oxazepane-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with high-purity standards for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.