Description

Boc-Glu(Otbu)-Obzl is a protected amino acid derivative widely used as a crucial building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates to construct complex peptide sequences with precise stereochemistry. It is primarily utilized by the pharmaceutical, biotechnology, and life science research sectors for the development of novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected glutamic acid derivative for the sequential assembly of peptides on resin.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for constructing peptide fragments in solution.
• Pharmaceutical Intermediate: Serves as a critical raw material in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Employed to introduce glutamic acid residues with orthogonal protecting groups for site-specific labeling or modification of biomolecules.
• Chemical Biology Research: Used in the synthesis of peptide probes, enzyme substrates, and inhibitors for biochemical studies.
• Custom Peptide Service: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing services.

Basic Information

Product Name	Boc-Glu(Otbu)-Obzl
CAS No.	910908-09-7
Molecular Formula	C22H33NO6
Molecular Weight	407.50 g/mol
Synonyms	Boc-Glu(OtBu)-OBzl; Boc-L-Glutamic acid 5-tert-butyl 1-benzyl ester; N-(tert-Butoxycarbonyl)-L-glutamic acid 1-benzyl 5-tert-butyl ester; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]pentanedioic acid 1-benzyl 5-tert-butyl ester; Boc-Glu(OBzl)-OtBu; Boc-Glu(OtBu)-OBn; N-Boc-L-glutamic acid α-benzyl γ-tert-butyl ester; L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1-(phenylmethyl) 5-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our Boc-Glu(Otbu)-Obzl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation	[α]20/D: -15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.