Description

Netupitant n-Oxide is a key pharmaceutical intermediate and metabolite of the antiemetic drug netupitant. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism and pharmacokinetics. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories involved in the synthesis and quality control of neurokinin-1 (NK1) receptor antagonists.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of netupitant and related therapeutic compounds.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies for drug metabolism and pharmacokinetic (DMPK) profiling.
• Quality Control & Impurity Testing: Serves as a known impurity or reference compound in HPLC and LC-MS methods for drug substance and product analysis.
• Research & Development: Employed in preclinical and clinical research to understand the metabolic pathways and safety profile of netupitant.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the controlled synthesis of high-purity netupitant API.

Basic Information

Product Name	Netupitant n-Oxide
CAS No.	910808-11-6
Molecular Formula	C30H33N5O3
Molecular Weight	511.62 g/mol
Synonyms	Netupitant N-Oxide; Netupitant Oxide; 2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]propanamide N-oxide; Akynzeo Impurity; Palonosetron and Netupitant Impurity; (2S)-2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide 1-oxide
EINECS	Contact for details

Quality Control

Our Netupitant n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical intermediates and reference standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.