Description

Boc-(S)-3-Thienylglycine is a high-purity, non-natural amino acid derivative featuring a thiophene side chain and an N-terminal tert-butoxycarbonyl (Boc) protecting group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling advanced research in medicinal chemistry. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutic agents, including protease inhibitors and bioactive peptide conjugates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly protease inhibitors and GPCR-targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a thienylglycine residue, introducing unique steric and electronic properties into peptide chains.
• Peptidomimetic Design: Serves as a backbone modification to create metabolically stable peptidomimetics with enhanced bioavailability and receptor selectivity.
• Chemical Biology Probes: Employed in the synthesis of labeled peptides or activity-based probes for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Potential intermediate in the development of novel bioactive compounds with specific modes of action.
• Material Science: Can be used to synthesize functionalized polymers or organic semiconductors that incorporate peptide-like structures.

Basic Information

Product Name	Boc-(S)-3-Thienylglycine
CAS No.	910309-12-5
Molecular Formula	C11H15NO4S
Molecular Weight	257.30 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-3-(thiophen-3-yl)propanoic acid; N-Boc-3-Thienyl-L-glycine; Boc-Thg-OH; tert-Butyloxycarbonyl-(S)-3-thienylglycine; (S)-2-(tert-Butoxycarbonylamino)-3-(3-thienyl)propionic acid; N-(tert-Butoxycarbonyl)-3-thienylglycine; Boc-L-3-Thienylglycine; Boc-(S)-3-(3-Thienyl)alanine
EINECS	Contact for details

Quality Control

Our Boc-(S)-3-Thienylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (typically ≥98%), and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.