Description

Tertiapin Q CAS NO 910044-56-3 is a high-purity, synthetic peptide analog of tertiapin, a potent and selective blocker of G protein-gated inwardly rectifying potassium (GIRK) channels. This compound is a critical research tool for neuroscientists and pharmacologists studying ion channel function, neuronal excitability, and cardiac electrophysiology. It is essential for academic research, pharmaceutical R&D, and biotechnology applications focused on channelopathies, pain signaling, and atrial fibrillation.

Application

• Neuroscience Research: A selective pharmacological tool for blocking GIRK channels in studies of synaptic transmission, neuronal plasticity, and neurotransmitter release.
• Cardiovascular Research: Used to investigate the role of GIRK channels in heart rate regulation and cardiac action potential duration, relevant to arrhythmia studies.
• Drug Discovery & Screening: Serves as a reference standard and positive control in high-throughput screening assays for novel GIRK channel modulators.
• Pain & Analgesia Studies: Applied in preclinical research to explore the involvement of GIRK channels in pain pathways and the mechanism of certain analgesics.
• Cellular Electrophysiology: Essential for patch-clamp experiments to characterize GIRK current properties in recombinant cell lines or native tissues.
• Biochemical Assays: Used in binding studies and functional assays to determine the potency and selectivity of new chemical entities.

Basic Information

Product Name	Tertiapin Q
CAS No.	910044-56-3
Molecular Formula	C119H187N41O33S4
Molecular Weight	2749.3 g/mol
Synonyms	Tertiapin-Q; TPN-Q; GIRK Channel Blocker Tertiapin Q; TPNQ; APQ; tertiapin Q peptide; Inward Rectifier Potassium Channel Inhibitor; Potassium Channel Kir3.x Blocker
EINECS	Contact for details

Quality Control

Every batch of Tertiapin Q is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and biological activity. Our products are suitable for critical research applications, with quality standards aligned with industry best practices for peptide therapeutics. Certificates of Analysis (COA) detailing HPLC purity, MS confirmation, amino acid analysis, and endotoxin levels are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. Aliquot into single-use vials to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.