Description

Levothyroxine Acyl Glucuronide is a key metabolite and reference standard used in the study of thyroid hormone metabolism and pharmacokinetics. This compound is essential for analytical laboratories and pharmaceutical developers requiring precise quantification and characterization of levothyroxine and its derivatives. It is primarily utilized by researchers and quality control specialists in the pharmaceutical, clinical diagnostics, and contract research organization (CRO) sectors.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the calibration and validation of analytical methods in drug development and quality control.
• Metabolite Identification & Profiling: Critical for in vitro and in vivo metabolism studies to understand the biotransformation pathways of levothyroxine.
• Bioanalytical Method Development: Used as a critical reagent in developing and optimizing HPLC, LC-MS, and LC-MS/MS assays for pharmacokinetic studies.
• Clinical Research & Diagnostics: Supports research into thyroid function disorders and the development of diagnostic assays.
• Impurity Characterization: Employed to identify and quantify glucuronidated impurities or metabolites in active pharmaceutical ingredient (API) batches.
• Regulatory Compliance Testing: Facilitates testing required for regulatory submissions to agencies like the FDA and EMA.

Basic Information

Product Name	Levothyroxine Acyl Glucuronide
CAS No.	909880-81-5
Molecular Formula	C30H37I4NO11
Molecular Weight	Contact for details
Synonyms	Thyroxine Glucuronide; T4 Glucuronide; L-Thyroxine O4'-Glucuronide; O4'-Glucuronyl-thyroxine; Levothyroxine Glucuronide Metabolite; (2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid glucuronide; LT4-Gluc
EINECS	Contact for details

Quality Control

Our Levothyroxine Acyl Glucuronide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and reference materials. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.