Description

N,N'-Bis[(S)-1-(tert-Butyldimethylsilyloxymethyl)Propyl]Ethanediamide is a high-purity chiral intermediate featuring tert-butyldimethylsilyl (TBDMS) protecting groups. This compound is critical for ensuring stereochemical integrity and reaction selectivity in advanced synthetic pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug candidates, particularly in stereocontrolled reactions.
• Asymmetric Synthesis: Used as a ligand or auxiliary precursor in catalytic asymmetric transformations to induce high enantioselectivity.
• Peptidomimetic Research: Serves as a constrained dipeptide analog or scaffold in the design of protease inhibitors and bioactive peptides.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified compounds for studying enzyme mechanisms and protein interactions.
• Process Chemistry Development: Evaluated for scalable routes in pilot plants and commercial manufacturing of optically pure substances.
• Academic & Industrial R&D: A valuable reagent for methodology development and exploring new synthetic routes in organic chemistry laboratories.

Basic Information

Item	Details
Product Name	N,N'-Bis[(S)-1-(tert-Butyldimethylsilyloxymethyl)Propyl]Ethanediamide
CAS No.	909567-52-8
Molecular Formula	C24H50N2O4Si2
Molecular Weight	486.84 g/mol
Synonyms	N,N'-Bis[(S)-1-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]propyl]ethanediamide; (S,S)-N,N'-Bis[1-((tert-Butyldimethylsilyloxy)methyl)propyl]oxalamide; TBDMS-protected chiral oxalamide derivative; Chiral bis-silyl ether oxalamide; (S,S)-Oxalamide bis-TBDMS ether
EINECS	Contact for details

Quality Control

Every batch of N,N'-Bis[(S)-1-(tert-Butyldimethylsilyloxymethyl)Propyl]Ethanediamide is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with data from HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Our quality commitment ensures the material meets the stringent requirements for pharmaceutical R&D and process development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.