Description

3-Chloro-4-Ethoxy-2-Fluorophenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those containing complex fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides with specific activity profiles.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The principal application is as a boronic acid reagent for palladium-catalyzed C-C bond formation to create biaryl and heterobiaryl compounds.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and diagnostic agents for biological target identification and validation.

Basic Information

Product Name	3-Chloro-4-Ethoxy-2-Fluorophenylboronic Acid
CAS No.	909122-50-5
Molecular Formula	C8H9BClFO3
Molecular Weight	217.42 g/mol
Synonyms	(3-Chloro-4-ethoxy-2-fluorophenyl)boronic acid; 2-Fluoro-3-chloro-4-ethoxyphenylboronic acid; 3-Chloro-4-ethoxy-2-fluorobenzeneboronic acid; Boronic acid, B-(3-chloro-4-ethoxy-2-fluorophenyl)-; 909122-50-5; AKOS005258033; FT-0698285; A839404
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Ethoxy-2-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality parameters. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.