Description

n-Fmoc-n-Phenyl-Glycine CAS NO 909114-68-7 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled incorporation of phenylglycine, a non-proteinogenic amino acid, into complex peptide sequences for pharmaceutical research and development. This compound is a critical building block for medicinal chemists and peptide manufacturers developing novel therapeutic peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key monomer for the automated, stepwise construction of custom peptide chains.
• Pharmaceutical R&D: Used in the synthesis of peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetic Design: Incorporation of the phenylglycine scaffold is valuable for creating modified peptides with enhanced stability, bioavailability, or receptor binding affinity.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new bioactive lead compounds.
• Bioconjugation: Can be used to introduce specific functional handles or linker moieties into peptides for labeling or conjugation purposes.
• Academic Research: A fundamental reagent in university and institutional labs studying peptide structure, function, and synthesis methodologies.

Basic Information

Product Name	n-Fmoc-n-Phenyl-Glycine
CAS No.	909114-68-7
Molecular Formula	C23H19NO4
Molecular Weight	373.40 g/mol
Synonyms	Fmoc-Phenylglycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]phenylglycine; N-Fmoc-2-amino-2-phenylacetic acid; (2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetic acid; Fmoc-Phg-OH; N-α-Fmoc-phenylglycine; N-(9-Fluorenylmethoxycarbonyl)-α-phenylglycine; Fmoc-α-phenylglycine
EINECS	Contact for details

Quality Control

Our n-Fmoc-n-Phenyl-Glycine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for advanced intermediates and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.5%
Water Content (KF)	≤0.5%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.