Description

1,1,1-Trifluoro-n-[(11Bs)-4-Oxido-2,6-Diphenyldinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Yl]Methanesulfonamide is a sophisticated organophosphorus compound featuring a unique dinaphthodioxaphosphepin core structure. This high-value specialty chemical serves as a key chiral ligand or catalyst precursor in advanced synthetic chemistry, enabling highly selective transformations. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams developing novel active ingredients and complex molecular architectures.

Application

• Asymmetric Catalysis: Employed as a chiral ligand in transition metal-catalyzed reactions, such as hydrogenation, cross-coupling, and C-H functionalization, for the synthesis of enantiomerically pure compounds.
• Pharmaceutical Intermediate Synthesis: A critical building block or catalyst in the multi-step synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Advanced Material Research: Used in the development of novel organic electronic materials or metal-organic frameworks (MOFs) due to its rigid, conjugated structure and coordination properties.
• Methodology Development: Serves as a benchmark or novel scaffold in academic and industrial research for developing new catalytic protocols in organic synthesis.
• Agrochemical Synthesis: Potential application in the synthesis of chiral, biologically active molecules for crop protection agents.

Basic Information

Item	Details
Product Name	1,1,1-Trifluoro-n-[(11Bs)-4-Oxido-2,6-Diphenyldinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Yl]Methanesulfonamide
CAS No.	908338-42-1
Molecular Formula	C37H21F3NO5PS
Molecular Weight	679.60 g/mol
Synonyms	(11bS)-4-Oxido-2,6-diphenyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl 1,1,1-trifluoromethanesulfonamide; (S)-TRIP TfNH; TfNH-(S)-TRIP; Chiral Phosphoric Acid Amide Derivative; (S)-3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate Triflamide; BINOL-based Phosphoramidate Ligand; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Every batch of our high-purity specialty chemicals is produced and verified under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and chiral integrity, which are critical for reproducible catalytic performance. A detailed Certificate of Analysis (COA) including results for chiral purity (HPLC), assay, and impurity profile is supplied with each shipment. Our standards align with cGMP principles for materials intended for pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container for extended periods to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.